3. Must a school have a minimum enrollment to apply?

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A positive association between an agent and an effect may be interpreted as implying causality, to a greater or lesser extent, if the following criteria are met: (a) there is not identifiable positive bias; (b) the possibility of positive confounding has been considered; (c) the association is unlikely to be due to chance alone; (d) the association is strong; and (e) there is a dose-response relationship (IARC, 1990).

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It is also recognized that risk management is a complex multidisciplinary procedure that is seldom codified or uniform, frequently unstructured, but which can respond to evolving input from a wide variety of sources (Stern, 1986).

1. What is the maximum number of schools that CAPE can nominate to the USDE for recognition?

In the case of substances for which the critical effect is not carcinogenicity, it is generally assumed that there is a level of exposure below which the probability for an adverse effect to occur is minimal, if not zero (i.e.

2. What if CAPE receives more exemplary applications from qualifying schools than it can nominate?


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Hazard identification is based on analyses of a variety of data that may range from observations in humans to analysis of structure-activity relationships.

9. What assessment verification must schools submit to CAPE?

Dose-response assessment is the process of characterizing the relationship between the dose of an agent administered or received and the incidence of an adverse health effect.

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organ-specific, neurological/behavioural, immunological, non-genotoxic carcinogenesis, reproductive or developmental), it is generally considered that there is a dose or concentration below which adverse effects will not occur (i.e.

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It is designed to address primarily two questions: (1) whether an agent may pose a health hazard to human beings, and (2) under what circumstances an identified hazard may be expressed.

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If a threshold has been assumed (e.g., for non-neoplastic effects and non-genotoxic carcinogens), traditionally, a level of exposure below which it is believed that there are no adverse effects, based on a no-observed-adverse-effect level (NOAEL) (approximation of the threshold) and uncertainty factors, has been estimated.

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Increasingly, however, the "benchmark dose", a model-derived estimate (or its lower confidence limit) of a particular incidence level (e.g., 5%) for the critical effect, is being proposed for use in quantitative assessment of the dose-response for such effects.

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There is no clear consensus on appropriate methodology for the risk assessment of chemicals for which the critical effect may not have a threshold (i.e.